Dr. Tom Reynolds (Jon Hall) returns to Africa, where he was born of missionary parents, to do research on medicines that are reputed to keep a "White Goddess" (Millicent Patrick) eternally young. With his friend Howard Ogden (Ray Montgomery) and his guide Charley Smart (James Fairfax), Tom rescues Trudy Vantyne (M'Liss McClure), a trader's daughter, from savages who capture and hypnotize her, planning to make her a rival White Goddess. Two escaped convicts, Atkins (Lucien Prival) and Vail (Robert Williams) persuade the White Goddess, in reality the wife of another escapee, to flee with the tribal riches, but all three are killed trying to escape.