Beautiful Strangers is about the interconnected lives of Joyce (Lovi Poe) and Kristine (Heart Evangelista). Joyce is a woman motivated by her big dreams. She applies at the Castillo Realty, one of the biggest real estate companies in the Philippines, to establish her name in Interior Designing so that she may start a family with Noel (Rocco Nacino) and provide for her family, but all her dreams are shattered into pieces when Ronaldo Castillo (Christopher de Leon) attempted to rape her and accidentally pushes her down the stairs. All along, Ronaldo thinks that he killed Joyce after he let Rigor (Kier Legaspi) burn her. Fortunately, Joyce is able to survive everything but she suffers from selective amnesia. She crosses paths with Kristine and will be called Lea.