A man and a woman who love each other have to confront the world, in order to defend their feelings. Andrés Bustamante has been sentenced to twelve years in the gloomy cliff jail. Colonel Miguel Santana's daughter Barbara helps him escape from jail and takes him to the arid desert to hide. They are chased by Miguel Santana who makes them go through many dangerous adventures in search for freedom. Desert Lovers is a passionate and adventurous love story that takes place between the 1950s and 1960s.