Second Chances is a story that will dramatically narrate how an opportunity can change someone's life and will also provide a powerful response to viewers' demand for validation that indeed, we all deserve a second chance. It revolves around the lives of four people - Lyra (Jennylyn Mercado), whose life suddenly changes when a tragedy befalls her family and she loses both her husband and son in an instant; Bernard (Raymart Santiago), a single father and widower who finds the meaning of life and how to love again when he meets Lyra; Rebecca (Camille Prats), the childhood friend of Lyra, and a bipolar who became addicted to drugs as she pines for the son she lost; and Jerome (Rafael Rosell), a lawyer who has always loved Lyra even before she married her late husband.