Josie & The Pussycats follows the adventures of a rock & roll band that comes across all sorts of adventures along the way. The group consists of Josie, their guitar-playing leader; Valerie, the brilliant tamborine-player; Melody, the naive and optimistic drummer; Alan, Josie's love-interest; Alexander, the group's cowardly manager; Alexandra, Alexander's pesky sister who constantly tries to upstage Josie and be Alan's main squeeze; and of course, Sebastian, Alexandra's fiesty cat.