After the body of murdered woman is found, nude and handcuffed, floating down the Hudson River in New York, a string of murders occur by an unseen serial killer who kills men by handcuffing them before killing them. Mac, a TV talk-show host, and Larry, a police detective, team up to try to find the killer and seek help from Virna, a clairvoyant young artist, who draws visions of the murders before they happen. As Mac and Larry try to establish a connection between the victims and the first female victim, who may have been sexually involved all of the male victims, Virna's further visions begin to point to her as the next victim as she unknowingly closes in on the killer's identity.