When Sherlock Holmes plummets down Reichenbach Falls, a natural time warp transports him into the year 2249. There he is patched up by Rigillian Dr. Wt'sn of Harley Str. Hospital. They soon team up with Holmes' great great grandniece, Yard Agent Mycroft Holmes. His first case is presented by Marshal BraveStarr, who is searching for a missing alien boy called Fleeder.