The race begins in Denver, Colorado when teams quickly jet off to their first location, Sao Paulo, Brazil where, upon landing, they must venture deep into the heart of the city to find their next clue at the Hotel Unique. Almost immediately, teams make their way by foot to Viaduto Santa Ifigenia, a pedestrian footbridge overlooking the highway and the Vale do Anhangabuau. One team struggles to locate the clue box, while other teams seem to find it with ease. At the bridge, teams are faced with their first detour and must choose between finding a local motorcycle shop, where they will have to assemble a motorcycle from scratch, or soar high above the city of San Paolo in a helicopter in order to locate a specific building where they will find their next clue.