Life and work in a police station of Rome. The chief of the station, Giovanna Scalise, has arrived in town after a long period passed in the city of Palermo, Sicily, where she fought against mafia. Now she catches criminals with the help of Mauro (the crazy guy of the group), Manrico (the cool one), inspector Ardenzi (who is married with Angela, the psychologist of the station), Parmesan (the old one) and the young Nina (who loves the handsome Benvenuti). Distretto di polizia is a TV series of action, sometimes dramatic, sometimes happy, with a peculiar attention to human affairs.