The show revolves around the life of an upper class Gujarati family, the Sarabhais, who live in a luxury apartment building in the upmarket Cuffe Parade area of South Mumbai. The family consists of Indravadan Sarabhai (Satish Shah) and his wife Maya (Ratna Pathak), who live in an apartment with their younger son Rosesh (Rajesh Kumar). Their older son Sahil (Sumeet Raghavan) and his wife Monisha Sarabhai (Rupali Ganguly) née Manisha Singh live in the apartment across the hallway. Maya considers the name Manisha middle class and renames her Monisha before their marriage. Monisha`s middle-class habits irk Maya. Monisha, on the other hand, does not appreciate Maya`s snooty and snobbish behaviour. Indravadan constantly derides Roshesh for being tied to his mother`s apron strings and for writing bad poetry. Maya and Roshesh consider Indravadan`s attitude towards Rosesh and his gregarious nature boorish. The ensuing conflict and comedy becomes Sarabhai vs Sarabhai.