In its first season, father-daughter pediatricians, Doctors Sean and Anne Jamison, run a free clinic in Oahu, Hawaii. Starting in the second season, very proper Dr. Austin Chaffee shares office space with Dr. Sean Jamison and finds the easy going manner of the latter difficult to adjust too. Mrs. Gruber, the rich widow who owns the clinic, was added to the series in the second season to develop problems that the Jamisons solved.