T2 is the story of Claire (Maricel Soriano) who is still reeling from the pain of the break-up of her childless marriage with Jeremy (Derek Ramsay). A social volunteer for a foundation that reunites children with their relatives, Claire decides to go to Samar to take her mind off her marital problems. She brings a young boy to Samar but on her way back faced a blocked road, forcing her and her companions to spend the night in an orphanage where she meets Angeli (Mica dela Cruz). The nuns at the orphanage requested Claire to bring Angeli to Tenement 2 where Angeli’s folks live. Strange and unexplainable occurrences take place when they arrived at Tenement 2, making Claire wonder about the real identity of Angeli.