Alexander and Beth's grandfather, Bratt Smith, have a brain disease. Doctor Rob can't figure out how did Bratt has brain disease. Alexander and Beth noticed their grandfather get blood from his nose and mouth. Alexander asks his father about to happen grandfather, but his father refused tells Alexander what's happened with Bratt Smith. At school, Alexander saw a man with a red face stand by a tree and a car passes him, he's disappeared. Beth and Alexander confused with the interpreter because the interpreter said "Be prepare..." and hang up. They went to the hospital to see their grandfather and tried to convince him explain them everything how he had brain disease, but their grandfather wants them to get out of the hospital before happen and he gave a note to them it said "Your friend is evil..." "Be prepare". He keeps it since he was in high school. Alexander and Beth wonder who his friend is. They have to figure out who is his friend.