Jenny Rice, a Chicago dog walker arrives to feed and walk Charlie, a client's dog only to find the animal comatose. Calling the dog's vet she is instructed to bring the animal to the emergency clinic by the fastest means possible. Without a car she stuffs the dog into a large suitcase and dashes to the elevated train station. An attractive con artist volunteers to help her carry the bag only to step off the train with it as the doors close. Jenny trapped on board must use all her guile and gumption to recover Charlie.