Set in 1988 West Virginia, Man Kills, Jesus Saves centers around a Bible Studies camp for children led by the ever 'hip' youth pastor Duane Sheppard Jr. As he and his collective of Christ-loving youth counselors begin setting up camp for the season, a series of strange happenings occur that rattle the members of the site and, in turn, lead to several murders committed by an unidentified killer. In the midst of this, Duane and the camp itself face the potential of scandal and condemnation due to long held rumors of inhumane treatment and 'gay correction' therapies surfacing in The Village Voice. Duane struggles to cover up the murders to avoid further bad publicity and attempts find the killer before things escalate to the point of no return.