Inspired by actual cases and experiences,Numb3rs depicts the confluence of police work and mathematics in solving crime. An FBI agent recruits his mathematical genius brother to help solve a wide range of challenging crimes in Los Angeles from a very different perspective.Numb3rs stars David Krumholtz as Charlie Eppes,Rob Morrow as Don Eppes,Judd Hirsch as Alan Eppes,Peter MacNicol as Larry Fleinhardt,Alimi Ballard as David Sinclair,Navi Rawat as Amita Ramanujan,Diane Farr as Megan Reeves,and Dylan Bruno as Colby Granger.Rob Morrow扮演的FBI探员和他那具备超乎常人数学天才的弟弟Charlie一起侦破了在L.A发生的大范围严重罪案。Charlie对案件独特的思考方式让Don的同僚Terry Lake 和David Sinclair 都感到十分惊讶。与此同时，Don和Charlie的父亲对于两个儿子专注执着的个性会否使彼此在工作中产生摩擦感到担心。Larry Fleinhardt 是Charlie的学院导师，他希望Charlie专注于学术研究而不是浪费无谓的精力帮助警方破案。