Most Likely is an ensemble comedy that revolves around the wedding of Kurt and Chloe, a free-spirited couple that, instead of planning a traditional wedding, decide to invite their closest friends to Kurt's family's vacation house in northern New Hampshire for the weekend. Among the guests are Chloe's lifelong friends - Beth, a talented but aimless aspiring writer; Mia, a recently divorced single mom who'd rather not be at a wedding; and Joe, Mia's best friend, who is recovering from the emotional fallout of a bad breakup. Unfolding over the course of the weekend leading up to Chloe and Kurt's nuptials, wine is poured (and other substances are imbibed), old friends are tested and new relationships begin.