Housefull is a family entertainer, showing the life of a Police Constable Ananthan, who continues to be a bachelor after 36. All marriage proposals are utter failures, many times due to minor reasons. At a crucial situation Ananthan marries Emily who works in a textile shop. Both families were against the marriage. Ananthan and Emily hopes that the birth of a baby may change the situation. But they were not blessed with a baby for a long time. At last when god blessed them, it was not one but 4 kids at a time. What happens after this weaves the humorous plot of the movie.